The Wright Center for Innovation in Biomedical Imaging at The Ohio State University is revolutionizing the interface between
clinical applications and state-of-the-art imaging. The Wright Center was established in 2003 through two grants totaling more
than $17 million, awarded to its director, Michael Knopp, MD, PhD. The center continues to earn funding and recognition through
innovative research endeavors that are supported, in part, by the state of Ohio.
The center collaborates with Case Western Reserve University in Cleveland; Philips Medical Systems of Highland Heights, Ohio;
and the Ohio Supercomputer Center in Columbus. The center provides imaging technologies to address current research
questions and works with clinical teams to optimize the efficiency of diagnoses and applied therapies, while contributing to
developing new treatment therapies.
The Wright Center is one of the few in the nation using the next
generation digital positron emission tomography-computed
tomography (PET/CT) imaging system in which digital silicon
photomultipliers replace the traditional photomultiplier tube,
resulting in better linearity and accuracy. The center also
is working to minimize the amount of radiation in PET scans,
while maximizing resolution. This advance in the use of low-dose PET scans has allowed for multiple serial PET/CT scans
to be performed in prospective clinical studies such as DBS
for traumatic brain injury, Alzheimer’s, obesity and other
applications. Furthermore, the center, along with collaborators
Philips Healthcare and Cardinal Health, has received grant
funding of $3 million to develop new radiopharmaceuticals
and imaging technologies for disease detection and diagnosis
using a next generation PET/MRI platform.
The center embodies both an academic and industrial environment that consists of multidisciplinary research teams. Although
many members of the teams focus exclusively on research efforts, the goals are tightly integrated with clinical concerns and
utilizations. Dr. Knopp is passionate about incorporating educational opportunities and embraces working with students of
varying levels. He attributes the success of the center to the collaborative atmosphere that is part of Ohio State and values
promoting the vision of a “research to patient care” continuum.
Michael Knopp, MD, PhD
Advances in the use of low-dose PET scans have allowed for multiple serial PET/CT scans
to be performed in prospective clinical studies such as deep brain stimulation and spinal